Defined full length laminin for PSC therapy

Why Biolaminin

Based on research, supported by science

Pluripotent stem cells (PSCs) hold immense promise in advancing regenerative medicine, given their capacity to differentiate into various cell types. However, harnessing this potential comes with inherent challenges like heterogeneity and genetic instability that need to be managed in the cell production process.

The natural stem cell niche protein laminin-521 (Biolaminin® 521) provides a scientifically validated approach to promote uniform cell growth and stabilize cell phenotype, genotype, and identity.

Compared to fragmented laminin products, non-specific tissue proteins, or undefined matrix extracts, the defined and physiologically relevant characteristics of the full-length laminin-521 lead to improved maintenance, expansion, and controlled differentiation of human ES and iPS cells.

Biolaminin 521 is compatible with numerous cell lines, independent of media, and performs across various large-scale production systems.

Biolaminin 521 CT is specifically designed for clinical applications with robust quality documentation to meet regulatory standards for approval and commercialization. The substrate stands out as the preferred option for maintaining the high quality and purity of therapeutic cells, supporting their functionality and integrity.

Our portfolio also covers tissue-specific laminin isoforms tailored for robust differentiation of specialized cell types such as DA neurons, pancreatic cells, and cardiomyocytes.

Truly harness the potential of PSCs for cell therapy – see the key advantages below.

Explore the full research grade portfolio tailored for your differentiation needs.

Biolaminin products have been scientifically proven to increase cell proliferation rates while maintaining genetic integrity and stemness. They enable the use of low-passage cell lines to generate clinically relevant quantities of differentiated cell types. Biolaminin coating is compatible with a range of large-scale production methods.

🡺 Designed for clinical applications

🡺 Animal origin-free

🡺 Media independent

🡺 Manufacturing control and traceability

🡺 A simple and compatible coating method

🡺 Consistent performance

🡺 Designed for clinical applications

🡺 Animal origin-free

🡺 Media independent

🡺 Manufacturing control and traceability

🡺 A simple and compatible coating method

🡺 Consistent performance

🡺 Designed for clinical applications

🡺 Animal origin-free

🡺 Media independent

🡺 Manufacturing control and traceability

🡺 A simple and compatible coating method

🡺 Consistent performance

🡺 Designed for clinical applications

🡺 Animal origin-free

🡺 Media independent

🡺 Manufacturing control and traceability

🡺 A simple and compatible coating method

🡺 Consistent performance

🡺 Designed for clinical applications

🡺 Animal origin-free

🡺 Media independent

🡺 Manufacturing control and traceability

🡺 A simple and compatible coating method

🡺 Consistent performance

Key advantages

Key advantages of Biolaminin 521

High cell yield

Biolaminin products have been scientifically proven to increase cell proliferation rates while maintaining genetic integrity and stemness. They enable the use of low-passage cell lines to generate clinically relevant quantities of differentiated cell types. Biolaminin coating is compatible with a range of large-scale production methods.

High reproducibility

Biolaminin products are fully defined which enables reproducible results and credible conclusions.

Genetically stable cell culture

Biolaminin 521 has a positive effect on stabilizing and homogenizing pluripotent gene expression profiles between hES cell lines.

Long-term pluripotency

Biolaminin 521 substrate recreates a biologically relevant hPSC milieu in vitro, promoting attachment, high survival, and robust long-term self-renewal of the cells.

Effective specialization

The more authentic culture environment primes the pluripotent stem cells for more efficient differentiation, enhanced cell maturation, polarization and organization of specialized cell types.

Biologically relevant

Without the right combination of laminin isoforms, cells and tissues become dysfunctional. Biologically relevant support improves cell authenticity and functionality.

Clinically compliant

Biolaminin 521 CT is specifically designed for clinical applications with robust quality documentation to meet regulatory standards for approval and commercialization. The high-quality substrate and comprehensive support facilitate the customer journey from concept to commercialization.

REMOVED 25.4.24: versions of Key Advantages

Key advantages of Biolaminin 521

➞ Enhances cell survival and proliferation from day zero

➞ Enables cell growth that utilizes the entire culture surface area

➞ Fully defined, recombinant matrix with lot-to-lot consistency

➞ For standardized protocols and credible conclusions

➞ Maintains stem cell pluripotency with stable genotype

Biolaminin 521 CT is specifically designed for clinical applications with robust quality documentation to meet regulatory standards for approval and commercialization. The high-quality substrate and comprehensive support facilitate the customer journey from concept to commercialization.

➞ Streamlined differentiation

➞ Enhanced cell maturation, polarization, and organization of specialized cell types

High cell yield

➞ Enhances cell survival and proliferation from day zero
➞ Enables cell growth that utilizes the entire culture surface area

Reproducible results

➞ Fully defined, recombinant matrix with lot-to-lot consistency
➞ For standardized protocols and credible conclusions

Stable pluripotency

➞ Maintains stem cell pluripotency with stable genotype

Clinically compliant

➞ Specifically designed for clinical applications with robust quality documentation to meet regulatory standards for approval and commercialization.
➞ High-quality substrate and comprehensive support
➞ Customer journey from concept to commercialization facilitated

Compatible across platforms

Controlled differentiation

➞ Streamlined differentiation
➞ Enhanced cell maturation, polarization, and organization of specialized cell types

Higher cell yield

➞ Enhances cell survival and proliferation from day zero

➞ Enables cell growth that utilizes the entire culture surface area

More stable cells for reproducible results

➞ Fully defined, recombinant matrix with lot-to-lot consistency

➞ Maintains stem cell pluripotency with stable genotype

➞ For standardized protocols and credible conclusions

Compatible all the way

➞ From a single cell to large-scale production with clinical compliance

➞ With automation, imaging, and a range of surface materials and media

➞ Unified matrix from stem cells to maturation

Our products

Discover our products

The MX521 stem cell substrate enables a high expansion rate, monolayer homogenous growth, and maintained pluripotency. Cells are genetically stable without karyotypic abnormalities.

  • Biolaminin 521 CTG (CT521)

    Human recombinant laminin 521

    Biolaminin 521 CTG is a full-length, human, recombinant laminin 521 substrate, the only one of its kind on the market, providing an optimal environment for feeder-free culture of human PSCs, MSCs and most anchorage-dependent progenitor cell types. CT521 is animal origin-free to the secondary level and designed for clinical studies.
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  • Biolaminin 521 MX (MX521)

    Human recombinant laminin 521

    Biolaminin 521 MX is the natural laminin for pluripotent stem cells and therefore reliably facilitates self-renewal of human ES and iPS cells in a chemically defined, feeder-free stem cell culture system. MX521 is animal origin-free to the secondary level.
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