Biorelevant culture of neural cells on Biolaminin substrates

Laminins are widely expressed in the nervous system and are essential for the development and function of neural cells. Biolaminins allow long-term culture of specialized neuronal cells and better purity of transplantable neural progenitors. See information on the specific nervous system compartments in the applications below.

Biolaminin Key Advantages

Several laminin isoforms are expressed and functional in the nervous system. Biolaminins have successfully been used to mimic this authentic cell microenvironment for improved differentiation of the cell types in nervous system. Using Biolaminin 521, patient-derived iPSCs can be specified to neuroepithelial stem cell lines and efficiently expanded and differentiated into neurons and glial cells.

All our matrices are chemically defined and animal origin-free, which makes them ideal substrates for each level of the scientific process – from basic research to clinical applications.

Our products have consistent composition and quality. This enables minimized variability between experiments and uniform pluripotency gene expression profiles between different cell lines.

Numerous scientists have found our products and finally succeeded in their specific stem cell application. The power of full-length laminins incorporated into various cell systems is well documented in scientific articles and clinical trials.

What our customers say…

“We have discovered LN521 is far superior to all other alternative ECMs we have tried for hPSC culture, and have switched all our hiPSC and hESC lines to LN521 for maintenance. We’ve also found LN521 performs best for the adherence and regional specification of NPCs and neurons across several CNS differentiation protocols, including the dorsal cortex, medial ganglionic eminence, ventral midbrain, and ventral hindbrain.”

Dr. Jonathan Niclis,

Univ. of Copenhagen, Denmark

  • Biosilk

    3D culture substrate

    Biosilk is a natural biomaterial made of recombinant spider silk protein, a useful tool for a wide range of 3D culture applications, such as organoid culture and other tissue engineering applications. Biosilk can be mixed with any Biolaminin matrix.
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  • Biosilk 521

    3D culture substrate

    Biosilk 521 is a natural biomaterial made of spider silk and laminin 521 – a biocompatible 3D culture mesh for expansion and long-term differentiation of human pluripotent stem cells and for organoid formation of various cell types.
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  • Biolaminin 521 CTG (CT521)

    Human recombinant laminin 521

    Biolaminin 521 CTG is a full-length, human, recombinant laminin 521 substrate, the only one of its kind on the market, providing an optimal environment for feeder-free culture of human PSCs, MSCs and most anchorage-dependent progenitor cell types. CT521 is animal origin-free to the secondary level and designed for clinical studies.
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  • Biolaminin 211 LN (LN211)

    Human recombinant laminin 211

    Biolaminin 211 supports the growth, survival, and differentiation of a wide range of tissue-specific cell types, including motor neurons, cardiac cells, and skeletal muscle cells.
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  • Biolaminin 221 LN (LN221)

    Human recombinant laminin 221

    Biolaminin 221 supports the growth, survival, and differentiation of a wide range of tissue-specific cell types, including cardiac cells and skeletal muscle cells.
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  • Biolaminin 111 LN (LN111)

    Human recombinant laminin 111

    Biolaminin 111 is commonly used as a general attachment protein for many cell types in vitro.
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  • Biolaminin 121 LN (LN121)

    Human recombinant laminin 121

    Biolaminin 121 can be used as a general attachment protein for most cell types in vitro – in particular for hepatic and neural differentiation and to enhance neurite outgrowth.
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